Schizostatin, a potent squalene synthase inhibitor from Schizophyllum commune: Isolation, structure elucidation, and total synthesis

DOI: 10.1016/0040-4039(95)01265-J

Source and publish data:

Tetrahedron Letters p. 6301 - 6304 (1995)

Update date:2022-08-11

Topics:

Authors:

Tanimoto, Tatsuo

Tsujita, Yoshio

Hamano, Kiyoshi

Haruyama, Hideyuki

Kinoshita, Takeshi

Hosoya, Tsuyoshi

Kaneko, Satoru

Tago, Keiko

Kogen, Hiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)01265-J

The novel schizostatin (1) has been isolated as a potent inhibitor of squalene synthase. Its structure elucidation and total synthesis are described. Synthesis of the Z-isomer 12 and its biological activity are also reported.

Full text of DOI:10.1016/0040-4039(95)01265-J

Products guided by the article

Product name:2-Butenedial, 2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2E)-

Cas No:79421-72-0

R&D Labs maybe for 79421-72-0

Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)

Contact:+86-13687004106

Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Shandong united-rising pharmaceutical cooperation.,ltd.

Contact:008653187965009

Address:171No., Jing5 Road, Shizhong District, Jinan, China
CHINA MEHECO CORPORATION

Contact:+86-10-67147360/67107388

Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China

Relevant to this article

Doi:10.1021/jo00978a003
(1972)
Novel 1,2,3-triazole derivatives as mimics of steroidal system—synthesis, crystal structures determination, hirshfeld surfaces analysis and molecular docking

Doi:10.3390/molecules26134059
(2021)
Doi:10.1021/cr60234a003
(1965)
A supramolecular bifunctional iridium photoaminocatalyst for the enantioselective alkylation of aldehydes

Doi:10.1039/d0dt02587a
(2020)
Electronic structure of ReS₂ and ReSe₂ from first-principles calculations, photoelectron spectroscopy, and electrolyte electroreflectance

Doi:10.1103/PhysRevB.60.15766
(1999)
Improved scalable syntheses of mono- and bis-urethane derivatives of ornithine

Doi:10.1248/cpb.49.1189
(2001)

Article Doi