Schizostatin, a potent squalene synthase inhibitor from Schizophyllum commune: Isolation, structure elucidation, and total synthesis

DOI: 10.1016/0040-4039(95)01265-J

Source and publish data:

Tetrahedron Letters p. 6301 - 6304 (1995)

Update date:2022-08-11

Topics:

Authors:

Tanimoto, Tatsuo

Tsujita, Yoshio

Hamano, Kiyoshi

Haruyama, Hideyuki

Kinoshita, Takeshi

Hosoya, Tsuyoshi

Kaneko, Satoru

Tago, Keiko

Kogen, Hiroshi

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Article abstract of DOI:10.1016/0040-4039(95)01265-J

The novel schizostatin (1) has been isolated as a potent inhibitor of squalene synthase. Its structure elucidation and total synthesis are described. Synthesis of the Z-isomer 12 and its biological activity are also reported.

Full text of DOI:10.1016/0040-4039(95)01265-J

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