Tetrahedron Letters p. 6301 - 6304 (1995)
Update date:2022-08-11
Topics:
Tanimoto, Tatsuo
Tsujita, Yoshio
Hamano, Kiyoshi
Haruyama, Hideyuki
Kinoshita, Takeshi
Hosoya, Tsuyoshi
Kaneko, Satoru
Tago, Keiko
Kogen, Hiroshi
The novel schizostatin (1) has been isolated as a potent inhibitor of squalene synthase. Its structure elucidation and total synthesis are described. Synthesis of the Z-isomer 12 and its biological activity are also reported.
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