79425-69-7Relevant academic research and scientific papers
Lithium alkoxide-promoted michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds
Mukaiyama, Teruaki,Tozawa, Takashi,Fujisawa, Hidehiko
, p. 1410 - 1411 (2007/10/03)
Michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds by using a catalytic amount of Lewis base such as lithium alkoxide in DMF proceeds smoothly to afford the corresponding Michael-adducts in good yields with moderate to high diastereoselectivities. This reaction can be reasonably explained by considering an alkoxide anion-initiated autocatalytic process.
ACCELERATION OF THE CONJUGATE ADDITION OF Ti "ATE" ENOLATES VIA LEWIS ACID CATALYSIS.
Bernardi, Anna,Cavicchioli, Marcello,Scolastico, Carlo
, p. 10913 - 10916 (2007/10/02)
The conjugate addition of Ti "ate" complexes of ketone enolates to α,β-unsaturated ketones can be accelerated by activating the substrate via complexation with t-BuMe2SiCl or trityl triflate.
Stereoselective Michael additions of titanium "ate" complexes of ketone and ester enolates
Bernardi, Anna,Dotti, Pierfranco,Poli, Giovanni,Scolastico, Carlo
, p. 5597 - 5606 (2007/10/02)
The conjugate addition of Ti "ate" complexes of ketone and ester enolates to α,β-unsaturated carbonyl compounds was studied. The reaction was found to be highly regio- and stereoselective. Compared to the lithium enolates, ketone enolate Ti complexes show
INFLUENCE OF ENOLATE GEOMETRY ON THE STEREOCHEMISTRY OF MICHAEL ADDITIONS OF KETONE ENOLATES TO α, β-UNSATURATED KETONES
Oare, David A.,Heathcock, Clayton H.
, p. 6169 - 6172 (2007/10/02)
Preformed lithium enolates of ketones react with acyclic α,β-unsaturated ketones to give 1,5-diketones in good chemical yields.A strong correlation exists between enolate geometry and product stereochemistry; enolates having the Z configuration provide anti addition products while E enolates usually provide the syn diastereomers.
