79438-31-6

Upstream product

• 4394-75-6 6-(chloromethyl)-4-methyl-2H-pyran-2-one 
• 603-35-0 triphenylphosphine 

Downstream Products

• 4377-67-7 4-Methyl-6-((E)-styryl)-pyran-2-one 
• 14631-42-6 4-Methyl-6-((1E,3E)-4-phenyl-buta-1,3-dienyl)-pyran-2-one 
• 50405-75-9 1-Hydroxy-4-methyl-6-((E)-styryl)-1H-pyridin-2-one 
• 50405-76-0 1-Hydroxy-4-methyl-6-((1E,3Z)-4-phenyl-buta-1,3-dienyl)-1H-pyridin-2-one 
• 68077-39-4 1-Hydroxy-4-methyl-6-(4-phenyl-butyl)-1H-pyridin-2-one 
• 50496-53-2 6-[(Z)-2-(4-Dimethylamino-phenyl)-vinyl]-1-hydroxy-4-methyl-1H-pyridin-2-one 
• 79438-22-5 1-Hydroxy-4-methyl-6-phenethyl-1H-pyridin-2-one 
• 14666-43-4 6-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-4-methyl-pyran-2-one 

Relevant academic research and scientific papers

The chemistry of antimicrobially active 1-hydroxy-2-pyridones

The unsaturated δ-keto esters obtained by condensation of acid chlorides with esters of di- or trialkyl-acrylic acids can be cyclized with hydroxylamine to yield 1-hydroxy-2-pyridones. However, in many cases a two-steps synthesis may be of advantage in preparative respect, the ketoesters being cyclized to 2-pyrones, which then are reacted with hydroxylamine in the presence of certain bases to give. The hydroxy-pyridones show pronounced antifungal activity in vitro as well as in experimental guinea pig dermatophytosis.