4377-67-7

Upstream product

• 100-52-7 benzaldehyde 
• 79438-31-6 (4-Methyl-2-pyron-6-yl-methyl)-triphenyl-phosphoniumchlorid 
• 4394-75-6 6-(chloromethyl)-4-methyl-2H-pyran-2-one 

Downstream Products

• 50405-75-9 1-Hydroxy-4-methyl-6-((E)-styryl)-1H-pyridin-2-one 
• 79438-22-5 1-Hydroxy-4-methyl-6-phenethyl-1H-pyridin-2-one 

Relevant academic research and scientific papers

The chemistry of antimicrobially active 1-hydroxy-2-pyridones

The unsaturated δ-keto esters obtained by condensation of acid chlorides with esters of di- or trialkyl-acrylic acids can be cyclized with hydroxylamine to yield 1-hydroxy-2-pyridones. However, in many cases a two-steps synthesis may be of advantage in preparative respect, the ketoesters being cyclized to 2-pyrones, which then are reacted with hydroxylamine in the presence of certain bases to give. The hydroxy-pyridones show pronounced antifungal activity in vitro as well as in experimental guinea pig dermatophytosis.