794451-98-2 Usage
Heterocyclic compound
Consists of a pyrazole ring and a pyridine ring
Structural features
Methyl and trifluoromethyl groups are present
Pharmaceutical applications
Potential to interact with biological systems and enzymes
Stability
Contributed by tetrahydro and methyl groups
Pharmacokinetic properties
May be influenced by tetrahydro and methyl groups
Lipophilicity
Enhanced by the trifluoromethyl group
Bioavailability and distribution
Potentially affected by the trifluoromethyl group
Further research needed
To explore the full range of potential uses and effects
Check Digit Verification of cas no
The CAS Registry Mumber 794451-98-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,4,4,5 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 794451-98:
(8*7)+(7*9)+(6*4)+(5*4)+(4*5)+(3*1)+(2*9)+(1*8)=212
212 % 10 = 2
So 794451-98-2 is a valid CAS Registry Number.
794451-98-2Relevant academic research and scientific papers
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
Ashton, Wallace T.,Sisco, Rosemary M.,Dong, Hong,Lyons, Kathryn A.,He, Huaibing,Doss, George A.,Leiting, Barbara,Patel, Reshma A.,Wu, Joseph K.,Marsilio, Frank,Thornberry, Nancy A.,Weber, Ann E.
, p. 2253 - 2258 (2007/10/03)
A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioisomerism, and substitution. In particular, one analog (74, DPP-IV IC50 = 26 nM) exhibited good oral bioavailability and acceptable half-life in the rat, albeit with rather high clearance.
