647863-25-0

Usage

Uses

Used in Organic Synthesis:
Tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is used as a building block in organic synthesis for the creation of a variety of chemical compounds. Its complex structure allows for the formation of diverse molecules with potential applications across different fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is utilized as a key intermediate in the synthesis of pharmaceuticals. Its presence can contribute to the development of new drugs with improved pharmacological properties.
Used in Fluorination of Organic Molecules:
The trifluoroacetyl group in tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is used for the purpose of introducing fluorine atoms into organic molecules. This is significant as the presence of fluorine can enhance the stability, reactivity, and lipophilicity of the resulting compounds, which is particularly valuable in the design of more effective drugs.
Used in the Pharmaceutical Industry:
Tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is used as a synthetic intermediate in the pharmaceutical industry for the production of various medications. Its role in the synthesis of drug candidates is crucial for the development of new therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 647863-23-8 tert-butyl 5-[(trimethylsilyl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate 
• 647863-24-9 tert-butyl 5-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 911636-87-8 tert-butyl 2,4-bis(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-7-carboxylate 
• 733757-89-6 6-tert-butoxycarbonyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine 
• 647863-27-2 tert-butyl 2-(4-chlorophenyl)-4-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7 (6H)-carboxylate 
• 911635-51-3 t-butyl 2-cyclopropyl-4-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate 
• 1022930-40-0 1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 853784-47-1 2-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine 
• 794451-98-2 1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine 
• 853784-23-3 3-trifluoromethyl-4,5,6,7-tetrahydro-isoxazolo[3,4-c]pyridine 

Relevant academic research and scientific papers

Integration of lead optimization with crystallography for a membrane-bound ion channel target: Discovery of a new class of AMPA receptor positive allosteric modulators

A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and effica

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I), and salts and solvates thereof are provided: Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE AGENT

Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEROF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein X, Y, Z, R1, R2 and R3 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein A, R1, R, R2 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.

PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.