794464-41-8

Upstream product

• 675-20-7 piperidin-2-one 
• 94363-58-3 1-(2,2,2-Trifluoro-acetyl)-piperidin-2-one 
• 611-71-2 (R)-Mandelic Acid 
• 382637-47-0 3-(4-fluorobenzyl)-piperidine 
• 1604008-31-2 (E)-tert-butyl 3-(4-fluorobenzylidene)-2-oxopiperidine-1-carboxylate 
• 1604009-01-9 (R)-(+)-tert-butyl 3-(4-fluorobenzyl)-2-oxopiperidine-1-carboxylate 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 483305-37-9 (E)-3-(4-fluorobenzylidene)piperidin-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 483305-46-0 (S)-3-(4-fluorobenzyl)-2-piperidone 

Relevant academic research and scientific papers

Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds

A highly enantioselective hydrogenation of exocyclic α,β-unsaturated carbonyl compounds catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) has been developed, giving the corresponding α-chiral cyclic lactones, lactams and ketones with high yields and excellent enantioselectivities (up to 99% yield and 99% ee). Remarkably, the hydrogen bond between the substrate and the catalyst plays a critical role in this transformation. The synthetic utility of this protocol has been demonstrated by efficient synthesis of chiral 3-(4-fluorobenzyl)piperidine, a key chiral fragment of bioactive molecules.

Stereoselective process for a CCR3 antagonist

A convergent, multikilogram, stereoselective synthesis of 1 is described. A key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from valerolactam in three steps using our recently discovered Ir-BDPP-catalyzed asymmetric hydrogenation. Anoth

Enantioselective hydrogenation of 3-alkylidenelactams: High-throughput screening provides a surprising solution

High-throughput screening of 256 potential catalysts (8 metal precursors × 32 phosphine ligands) has identified [(BDPP)Ir(COD)]BF4 as a catalyst for the enantioselective hydrogenation of 3-alkylidenelactams. This result is surprising given the