382637-47-0

Basic information

• Product Name: 3-(4-FLUORO-BENZYL)-PIPERIDINE
• Synonyms: 3-(4-FLUORO-BENZYL)-PIPERIDINE;3-4-fluorobenzy1-piperidine-1-carboxylic acid tert-buty1-ester;tert-butyl 3-(4-fluorobenzyl)piperidine-l-carboxylate;3-[(4-fluorophenyl)methyl]piperidine
• CAS NO: 382637-47-0
• Molecular Formula: C₁₂H₁₆FN
• Molecular Weight: 193.26
• Mol File: 382637-47-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 276.6°C at 760 mmHg
• Flash Point: 121.1°C
• Appearance: /
• Density: 1.044g/cm³
• Vapor Pressure: 0.00475mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 3-(4-FLUORO-BENZYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-BENZYL)-PIPERIDINE(382637-47-0)
• EPA Substance Registry System: 3-(4-FLUORO-BENZYL)-PIPERIDINE(382637-47-0)

Safety Data

• Hazardous Substances Data: 382637-47-0(Hazardous Substances Data)

Usage

General Description

3-(4-Fluoro-benzyl)-piperidine is a chemical compound composed of a piperidine ring, a six-membered ring with one nitrogen atom, attached to a fluoro-benzyl group. 3-(4-FLUORO-BENZYL)-PIPERIDINE exhibits the properties of both the piperidine and the fluoro-benzyl, combining their characteristics. This chemical's structure and components could make it a basis for creating a variety of pharmaceuticals as both groups have notable uses in the pharmaceutical industry. The fluoro-benzyl can act as a flurophore while the piperidine ring exhibits basic properties, making it useful in the creation of drugs. However, the detailed properties, interactions, and potential uses of 3-(4-Fluoro-benzyl)-piperidine need further investigation and research.

InChI:InChI=1/C12H16FN/c13-12-5-3-10(4-6-12)8-11-2-1-7-14-9-11/h3-6,11,14H,1-2,7-9H2

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 382637-45-8 t-Butyl (+)-3-(4-fluorobenzyl)-1-piperidinecarboxylate 
• 89901-51-9 (4-fluorophenyl)(pyridin-3-yl)methanol 
• 94363-58-3 1-(2,2,2-Trifluoro-acetyl)-piperidin-2-one 
• 675-20-7 piperidin-2-one 
• 382637-43-6 tert-butyl 3-(4-fluorobenzylidene)piperidin-1-carboxylate 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 794464-41-8 (R)-3-(4-fluorobenzyl)piperidine 
• 275812-32-3 N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-N'-((1R,2S)-2-{[3(S)-(4-fluorobenzyl)piperidinyl]methyl}cyclohexyl)urea 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

Provided are a substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Efficient preparation of (3S)-3-(4-fluorobenzyl)piperidinium mandelate

Methods for the preparation of (3S)-3-(4-fluorobenzyl)piperidine (2) and its mandelate salt (9) are described. The first generation synthesis started from 3-benzylpiperidone, and required Boc protection of the nitrogen for efficient separation of the enantiomers using chromatography on a chiral stationary phase. Subsequently, a resolution method using (R)-mandelic acid, produced high %ee salt 9 after recrystallization and eliminated the need for Boc protection. The third generation route, starting from pyridine-3- carboxaldehyde, led to a streamlined synthesis of racemate 2 and was optimized for producing multi-hundred gram quantities of the chiral salt.