79447-10-2

Upstream product

• 92-52-4 biphenyl 
• 1711-05-3 m-anisoyl chloride 
• 147678-16-8 1-(biphenyl-4-yl)-1-(3-methoxyphenyl)methanol 

Downstream Products

• 79446-88-1 3-Biphenyl-4-yl-3-hydroxy-3-(3-methoxy-phenyl)-propionic acid ethyl ester 
• 1380855-46-8 (E,Z)-4-(1,1'-biphenyl-4-yl)-3-methoxycarbonyl-4-(3-methoxyphenyl)but-3-enoic acid 
• 79446-95-0 (R)-3-Biphenyl-4-yl-3-hydroxy-3-(3-methoxy-phenyl)-propionic acid 
• 86428-96-8 Biphenyl-4-yl-(3-hydroxy-phenyl)-methanone 

Relevant academic research and scientific papers

Crystal structures of two 4-phenylbenzophenones

Two 4-phenylbenzophenones (I) and (II) are synthesized via Friedel-Crafts reactions. There are four crystallographically independent molecules with different conformations in the crystal structure of [1,1′-biphenyl]-4- yl(2-chlorophenyl)methanone (I). Crystals are orthorhombic, Pca21, C19H13ClO, a = 13.699(3) A, b = 8.9385(17) A, c = 46.836(9) A; V = 5735(2) A3, Z = 16, d x = 1.356 g/cm3. Torsion angles between the biphenyl rings are between 28.5 and 30.8. Several C-H.O and C-H.Cl hydrogen bonds and weak π-π stacking contacts consolidate the crystal. Crystals of [1,1′-biphenyl]-4- yl(3-methoxyphenyl)methanone (II) are orthorhombic, Pbca, C20H 16O2, a = 7.8179(15) A, b = 16.003(3) A, c = 23.345(5) A; V = 2920.7(10) A3, Z = 8, d x = 1.311 g/cm3. The torsion angle between the biphenyl rings is 28.1 and C-H.O hydrogen bonds are observed in compound (II).

PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS

Described herein are compounds (III) comprising an indeno[2',3', 3, 4] naptho [1,2-b] pyran structure. Such compounds may be useful for their photochromic properties, and be use in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.

PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS

Described herein are compounds generally comprising an indeno[2′,3′:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.

Syntheses of Asymmetrical Diaryl and Aryl Alkyl Ketones as Possible Non-steroidal Antiprogestational Agents

A number of asymmetrical diaryl and aryl alkyl ketones have been synthesised as possible non-steroidal antiprogestational agents.Evaluation of these compounds as competitive inhibitors of progesterone binding to uterine cytosol progesterone receptors of rabbit and human indicates that 3-methyl-4'-phenylbenzophenone (2) exhibits marginal activity in both the cases.However, this compound has been found to be inferior to R 5020 and d-norgestrel.

Friedel-Crafts Aroylation of Benzene and Biphenyl in Methylene Chloride

Reactions of acid chlorides of o-, m- and p-toluic acids, p-methoxy- and 3,4-methylenedioxybenzoic acids with biphenyl in the presence of anhydrous AlCl3 in methylene chloride have been studied.Of these, only the reactions of o-, m- and p-toluoly chlorides with biphenyl indicates inter- and intramolecular methylene insertions in the reaction products.It is observed that the 2-, 3- and 4-methylbenzophenones, formed as intermediates, participate in the methylene insertion reactions.In a few cases, besides methylene insertion, methyl insertion has also occurred.Unlike these reactions, the reaction of o-toluoyl chloride with benzene in presence of anhydrous AlCl3 in methylene chloride gives 2-methyl-3-(p-benzylphenyl)benzophenone.The structural assignment of these products are made on the basis of their PMR and mass spectra.