794500-77-9

Upstream product

• 782482-51-3 3-{tert-butyl[(2S)-2-(2,4-difluorophenyl)-2-hydroxyethyl]amino}propanenitrile 
• 814-49-3 diethyl chlorophosphate 
• 330156-49-5 (S)-2-chloro-1-(2’,4’-difluorophenyl)ethanol 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 782482-50-2 (1S)-2-(tert-butylamino)-1-(2,4-difluorophenyl)ethanol 

Downstream Products

• 455957-94-5 (3S,4R)-N-tert-butyl-4-(2,4-difluoro-phenyl)-pyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3- carboxylic acid

(Chemical Equation Presented) A practical asymmetric synthesis of N-tert-butyl disubstituted pyrrolidines via a nitrile anion cyclization strategy is described. The five-step chromatography-free synthesis of (3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrr

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PYRROLIDINE CARBOXYLIC ACIDS

A novel process is provided for the preparation of pyrrolidine carboxylic acids, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of d