794514-81-1

Basic information

• Product Name: 4-Pentenoic acid, 2-[[(2-nitrophenyl)sulfonyl]amino]-, methyl ester, (2S)-
• CAS NO: 794514-81-1
• Molecular Formula: C12H14N2O6S
• Molecular Weight: 314.319
• Mol File: 794514-81-1.mol

Chemical Properties

• CAS DataBase Reference: 4-Pentenoic acid, 2-[[(2-nitrophenyl)sulfonyl]amino]-, methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentenoic acid, 2-[[(2-nitrophenyl)sulfonyl]amino]-, methyl ester, (2S)-(794514-81-1)
• EPA Substance Registry System: 4-Pentenoic acid, 2-[[(2-nitrophenyl)sulfonyl]amino]-, methyl ester, (2S)-(794514-81-1)

Safety Data

• Hazardous Substances Data: 794514-81-1(Hazardous Substances Data)

Upstream product

• 16338-48-0 L-allylglycine 
• 67-56-1 methanol 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 50299-15-5 methyl (S)-allylglycinate 

Downstream Products

• 794514-83-3 methyl (S)-2-(N-(3-methylenehexyl)-N-(2-nitro-phenylsulfonyl)-amino)-pent-4-enoate 
• 1089133-49-2 (S)-methyl 2-(N-(3-(cyclopropylmethyl)-3-butenyl)-2-nitrophenylsulfonamide)-4-pentenoate 
• 141083-85-4 (S)-methyl 1,2,3,6-tetrahydropyridine-2-carboxylate 
• 941585-96-2 methyl 6-N-((2′S)-1′-N-(2′′-nitrophenylsulfonyl)-5′-n-propyl-2′,3′,6′,7′-tetrahydro-1H-azepine-2′-carbonyl)-α-thiolincosaminide 
• 794514-84-4 methyl (S,Z)-1-(2-nitrophenylsulfonyl)-5-propyl-2,3,6,7-tetrahydro-1H-azepine-2-carboxylate 
• 1089133-09-4 (2S)-1-(2-nitrophenylsulfonyl)-5-n-propyl-2,3,6,7-tetrahydro-1H-azepine-2-carboxylic acid 

Relevant articles and documents

SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS

The present invention relates to compounds of the general formula (I) having a selective FKBP51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with

LINCOSAMIDE DERIVATIVE, AND ANTIBACTERIAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

LINCOMYCIN DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R1 represents a halide, nitro, substituted C1-6 alkyl, optionally substituted amino, C1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, all of R4, R5, and R6 represent a hydrogen atom, R7 represents C1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.