794520-99-3Relevant academic research and scientific papers
Synthesis of Defined and Functionalized Glycans of Lipoteichoic Acid: A Cell Surface Polysaccharide from Clostridium difficile
Yu, Kang,Bi, Ningning,Xiong, Chenghe,Cai, Shuihong,Long, Zhongzhu,Guo, Zhongwu,Gu, Guofeng
, p. 3123 - 3126 (2017)
Two structurally defined, functionalized glycans of lipoteichoic acid (LTA, also known as PS-III) from C. difficile, which have one or two repeating units of LTA linked to the core trisaccharide, were efficiently synthesized via a convergent [2 + 3] or [2 + 2 + 3] strategy. The α-linkage of both N-acetylglucosamine residues in the repeating unit were constructed with glycosyl imidates of azidosugars as donors, while the phosphodiester bridges between the oligosaccharides were fashioned using H-phosphonate chemistry. Both synthetic targets contained a 3-aminopropyl group at the core trisaccharide reducing end, facilitating their conjugation to other biomolecules to afford conjugates useful for various biological studies and applications.
Total synthesis of bidensyneosides A2 and C: Remarkable protecting group effects in glycosylation
Gung, Benjamin W.,Fox, Ryan M.
, p. 9405 - 9415 (2007/10/03)
Bidensyneosides are a group of five recently identified polyacetylenic glucosides from Bidens parviflora WILLD, a traditional Chinese medicinal plant that contains rich bioactive natural products. It was shown that bidensyneosides inhibited both histamine
