794521-41-8Relevant academic research and scientific papers
An approach to the site-selective deoxygenation of hydroxy groups based on catalytic phosphoramidite transfer
Jordan, Peter A.,Miller, Scott J.
, p. 2907 - 2911 (2012/05/20)
Selective: The deoxygenation of simple and complex natural products employing a readily synthesized phosphoramidite and tetrazole catalysts can be executed as a two-step process, without the need to isolate intermediate deoxygenation precursors. Furthermore, a peptide-based tetrazole catalyst controls the site selectivity of deoxyerythromycin synthesis (see scheme), thus overcoming the notorious challenges with unprotected erythromycin A. Copyright
Radical deoxygenation of hydroxyl groups via phosphites
Zhang, Liming,Koreeda, Masato
, p. 13190 - 13191 (2007/10/03)
A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product of the original alcohol. Copyright
