794533-53-2Relevant academic research and scientific papers
Approach to 3-(Cyclo)alkylpiperidines through 'sp3-sp3 via sp2-sp3' Coupling
Subota, Andrii I.,Grygorenko, Oleksandr O.,Valter, Yevheniia B.,Tairov, Maxim A.,Artamonov, Oleksiy S.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.
supporting information, p. 408 - 411 (2015/02/19)
The idea of introducing (cyclo)alkyl substituents at the C-3 atom of the piperidine ring, that is, formal sp3-sp3 retrosynthetic disconnection, is implemented through a two-step reaction sequence including directed ortho metalation of a pyridine derivative and the subsequent quenching with a carbonyl compound, followed by catalytic hydrogenation. This robust but very efficient method allows for multigram preparation of sp3-rich 3-(cyclo)alkylpiperidines, which are valuable building blocks for medicinal chemistry and other areas.
Sulfone derivatives as 5-HT7 receptor ligands
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Page/Page column 11, (2010/02/09)
The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2??I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically
