794575-13-6Relevant academic research and scientific papers
Enzymatic desymmetrization/resolution of epoxydiols derived from 1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone and 5,8-dihydroxy-1,4- naphthoquinone
Betts, Russell L.,Murphy, Sean T.,Johnson, Carl R.
, p. 2853 - 2860 (2007/10/03)
The enzymatic desymmetrization/resolution of epoxydiols generated from the basic epoxidation and reduction of 1,4-naphthoquoinone, 5-hydroxy-1,4- naphthoquinone and 5,8-dihydroxy-1,4-naphthoquinone is described. 2,3-Epoxy-1α,2α,3α,4 α-tetrahydronaphthalene-1,4-diol and 5,8-diallyloxy-2,3-epoxy- 1α,2α,3α,4 α-tetrahydronaphthalene-1,4-diol were desymmetrized in the presence of isopropenyl acetate using Burholderia cepacia lipase and Candida antartica lipase B, respectively. An enzymatic resolution of 8-benzyloxy-2,3-epoxy-1α,2α,3 α,4α-tetrahydronaphthalene-1,4-diol using B. cepacia lipase in isopropenyl acetate is also described.
