794587-08-9

Upstream product

• 66248-79-1 ethyl 4,4-dimethyl-3-oxo-hex-5-enoate 
• 794587-07-8 {(1R,3S,5R,6S,7S)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6,7-dihydroxy-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-1-yl}-acetic acid ethyl ester 
• 794587-06-7 {(1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-6-en-1-yl}-acetic acid ethyl ester 
• 795298-26-9 [(4R,6R)-2-(1,1-Dimethyl-allyl)-4,6-divinyl-[1,3]dioxan-2-yl]-acetic acid ethyl ester 
• 794587-16-9 [(1R,3S,5R)-3-(2-Hydroxy-ethyl)-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-6-en-1-yl]-acetic acid ethyl ester 
• 794587-04-5 ((1R,3R,5R)-8,8-Dimethyl-3-vinyl-2,9-dioxa-bicyclo[3.3.1]non-6-en-1-yl)-acetic acid ethyl ester 

Downstream Products

• 794587-02-3 Acetic acid (1R,3S,5R,7S)-1-[(2R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-7-yl ester 
• 794587-19-2 (1R,3S,5S,7S)-1-[(2R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-ol 
• 794587-12-5 (1R,3S,5R)-1-[(2R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-03-4 (1R,3S,5R)-1-[(E)-4-(tert-Butyl-dimethyl-silanyloxy)-penta-2,4-dienyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-11-4 (1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-1-((E)-4-oxo-pent-2-enyl)-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-09-0 {(1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-7-oxo-2,9-dioxa-bicyclo[3.3.1]non-1-yl}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of the bryostatin 1 northern hemisphere (C1-C16) via desymmetrization by ketalization/ring-closing metathesis

(Chemical Equation Presented) Synthesis of the northern hemisphere (C1-C16) of bryostatin 1, a potent anticancer agent, has been accomplished in 14 steps and 11% overall yield via desymmetrization by ketalization/ring-closing metathesis. A 2,9-dioxabicycl