794588-63-9Relevant articles and documents
Ring-closing metathesis: A powerful tool for the synthesis of simplified salicylihalamide-based V-ATPase inhibitors
Lebreton, Sylvain,Xie, Xiao-Song,Ferguson, Deborah,De Brabander, Jef K.
, p. 9635 - 9647 (2007/10/03)
Based on our synthetic strategy developed for the total synthesis of the macrocyclic salicylate natural product salicylihalamide, we describe herein the synthesis of a series of simplified salicylihalamide-based analogs. Alterations in the aromatic fragment, the macrolactone scaffold and side-chain were evaluated for in vitro inhibition of V-ATPase activity and human tumor cell growth. Graphical abstract.