79459-15-7Relevant articles and documents
Method for continuously preparing vanillin and syringaldehyde
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Paragraph 0023-0031; 0032; 0033; 0034, (2020/01/08)
The invention relates to the technical field of organic synthesis, in particular to a method for continuously preparing vanillin and syringaldehyde. According to the method for continuously preparingthe vanillin and the syringaldehyde, the vanillin and the syringaldehyde are continuously synthesized and produced by taking the p-hydroxy benzaldehyde as the raw material, and the vanillin and the syringaldehyde are obtained by directly etherifying brominated products without refining in the process, so that the aims of shortening the process, improving the yield, reducing the cost, being safe and environment-friendly and easily realizing industrial production are achieved.
Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions
Jiang, Jian-An,Chen, Cheng,Huang, Jian-Gang,Liu, Hong-Wei,Cao, Song,Ji, Ya-Fei
supporting information, p. 1248 - 1254 (2014/03/21)
A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds. The ligand- and additive-free Cu(OAc)2-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of significant value for both fundamental research and practical applications.
