79476-36-1

Basic information

• Product Name: Pyridine, 3,3'-(1H-pyrazole-3,5-diyl)bis-
• CAS NO: 79476-36-1
• Molecular Formula: C13H10N4
• Molecular Weight: 222.249
• Mol File: 79476-36-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 3,3'-(1H-pyrazole-3,5-diyl)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3,3'-(1H-pyrazole-3,5-diyl)bis-(79476-36-1)
• EPA Substance Registry System: Pyridine, 3,3'-(1H-pyrazole-3,5-diyl)bis-(79476-36-1)

Safety Data

• Hazardous Substances Data: 79476-36-1(Hazardous Substances Data)

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 
• 6327-87-3 1,3-bis(pyridin-3-yl)propane-1,3-dione 
• 500-22-1 3-pyridinecarboxaldehyde 
• 2510-23-8 3-Ethynylpyridine 
• 129485-45-6 (2Z)-3-hydroxy-1,3-di(3-pyridinyl)-2-propen-1-one 

Relevant articles and documents

A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.

REACTION OF 1-PYRIDYL-1,3-BUTANEDIONES AND 1,3-DIPYRIDYL-1,3-PROPANEDIONES

Reduction of diketones I with zinc and formic acid gives monoketones II.Diketones Ia, IIIb, IIIc are converted with hydrazines to pyrazoles VIa, IVa, IVb, V.Methiodides VII are reduced with sodium borohydride to derivatives of 1-methyl-3-piperideine VIII-