79492-10-7Relevant academic research and scientific papers
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents
Amin, Kamelia M.,Rahman, Doaa E. Abdel,Al-Eryani, Yasmin A.
, p. 5377 - 5388 (2008/12/20)
Some new substituted coumarinylthiazolines, coumarinylthiazolidin-4-ones, and substituted chromenothiazoles were synthesized and evaluated for anticonvulsant activity. Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice. Compounds 3b, 6b, and 7b were the most active of the series against PTZ induced seizures. Compound 7b provided anticonvulsant activity (PD50 = 95 mg/kg, ip) at a dose 200 mg/kg compared to phenobarbital (PD50 = 16 mg/kg, ip) at a dose 30 mg/kg (90% protection). No clear correlation was observed between the antiepileptic activity and molecular lipophilicity descriptors of the tested compounds.
Synthesis of biologically active thiazolo-benzopyranyl-s-triazine derivatives
Mulwad,Shirodkar, Jyoti M.
, p. 621 - 626 (2007/10/03)
6-Amino-2-oxo-2H [1]-benzopyran on oxidative cyclisation with potassium thiaocynate, acetic acid and bromine at 0-5°C gives 2-amino-7H [6]- thiazolo [5,4-d] benzopyran-7-one 1, which on treatment with cyanuric chloride in alcohol gives 2-(2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-6-dichloro-s-triazine 2. 6-Amino-2-oxo-2H [1]-benzopyran on refluxing with ammonium thiocynate in hydrochloric acid and ethanol gives 6-thioureido-2H [1]-benzopyran-2-one 3. Compound 2 on refluxing with 3 in alcohol gives 2-(2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-(6″-thioureido-2″H-[1″]-2 ″-oxo-benzopyranyl)-6-chloro-s-triazine 4. The similar reaction is repeated on 4 to give 2- (2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-(6″-thioureido-2″H [1″]-2″-oxo benzopyranyl)-6-(6?-thioureido-2?H-[1?]-2 ?-oxo-benzopyranyl)-s-triazine 5. The structures of all compounds are confirmed on the basis of analytical and spectral data. Some of the compounds show significant antibacterial activity.
Some Reactions of Aminocoumarins
Merchant, J. R.,Martyres, Gail,Venkatesh, M. S.
, p. 493 - 495 (2007/10/02)
Aminocoumarins (Ia-f) react with potassium thiocyanate under different conditions to give benzopyranothioureas (II) and 2-aminobenzopyranothiazoles (III).With sodium cyanate some benzopyranoureas (IV) are obtained.
