79492-55-0Relevant academic research and scientific papers
An efficient synthesis of 4,6-diarylnicotinonitrile-acetamide hybrids via 1,2,3-triazole linker as multitarget microbial inhibitors
El-Sayed, Hassan A.,Moustafa, Ahmed H.,Masry, Asmaa A.,Amer, Atef M.,Mohammed, Samar M.
, p. 275 - 285 (2021/10/21)
An efficient and smart approach for design and synthesis of a novel series of nicotinonitrile-1,2,3-triazole-acetamide hybrids was described. The synthetic methodology was commenced with preparation of acetylene derivatives via alkynylation of 2-oxonicotinonitrile with propargyl bromide under mild basic catalyst (pot. carbonate). The facile click cycloaddition reaction of alkynes 2a-f and azido-acetamides 3-5 in the presence of catalytic Cu(I) in H2O/tetrahydrofuran (THF) was utilized for the synthesis of target molecules 6a-l. Triazoles 6c, d, f, and 6i have highly activity against the four pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus) and two pathogenic fungi (Candida albicans and Aspergillus flavus) with minimum inhibitory concentration (MIC) in between 0.5 and 4?μg/ml for bacteria and 0.5 and 8?μg/ml for fungi.
Malononitriles and Cyanoesters: Part VII- Diaryl- and Dithienylpropenones and -cyanopyridines and Their Molluscicidal Activity
Latif, N.,Asaad, F. M.,Girgis, N. S.
, p. 463 - 466 (2007/10/02)
2-Amino-3-cyano-4,6-disubstituted-pyridines (6) and 3-cyano-4,6-disubstituted-pyridin-2-ones (10) are obtained by reacting the corresponding propenones (1) with malononitrile and ethyl cyanoacetate, respectively, in the presence of ammonium acetate.The compounds (6) and (10) can be readily obtained by reacting the corresponding ylidene-malononitriles (8) and -cyanoesters (9) with the appropriate ketone.Molluscicidal activity of the compounds is also discussed.
