79496-61-0

Basic information

• Product Name: 5-Hexyn-1-ol, methanesulfonate
• Synonyms: mesylate of hex-5-yne-1-ol;hex-5-ynyl mesylate;hex-5-ynyl methanesulphonate;hex-5-yn-1-methane sulfonate;hex-5-yn-1-yl methanesulfonate;5-hexynyl methanesulfonate
• CAS NO: 79496-61-0
• Molecular Formula: C7H12O3S
• Molecular Weight: 176.236
• Mol File: 79496-61-0.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 5-Hexyn-1-ol, methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hexyn-1-ol, methanesulfonate(79496-61-0)
• EPA Substance Registry System: 5-Hexyn-1-ol, methanesulfonate(79496-61-0)

Safety Data

• Hazardous Substances Data: 79496-61-0(Hazardous Substances Data)

Upstream product

• 928-90-5 5-hexyl-1-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 92610-64-5 1,1-Bis(2,2,2-trifluorethoxy)cyclohexan 
• 85355-26-6 cyclohexenyl trifluoroethyl ether 
• 15295-69-9 hept-6-ynenitrile 
• 145782-21-4 N-(hex-5-yn-1-yl)-4-methylbenzenesulfonamide 
• 146407-26-3 1-(N-benzylamino)-5-hexyne 
• 1310563-89-3 1-benzyl-2-methyl-2-(trifluoromethyl)piperidine 
• 1354695-60-5 C₁₃H₁₆FNO₂S 
• 1380099-92-2 (E)-N-benzyl-6-iodohex-5-en-1-amine 
• 1380099-93-3 (E)-6-iodo-N-(4-methoxybenzyl)hex-5-en-1-amine 
• 1380100-01-5 (E)-1-(4-methoxybenzyl)-2-styrylpiperidine 
• 1380100-04-8 (E)-1-(4-methoxybenzyl)-2-(3-nitrostyryl)piperidine 
• 1380100-05-9 (E)-1-benzyl-2-(4-methoxystyryl)piperidine 
• 1380100-06-0 (E)-1-(4-methoxybenzyl)-2-(2-methoxystyryl)piperidine 
• 1380100-09-3 (E)-tert-butyl (4-(2-(1-methylpiperidin-2-yl)vinyl)phenyl) carbonate 

Relevant articles and documents

A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning

Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located in the central nervous system and neuro-muscular junctions. One major drawback of these charged acetylcholinesterase reactivators is their poor ability to cross the blood-brain barrier. In this study, we propose to evaluate glucoconjugated oximes devoid of permanent charge as potential central nervous system reactivators. We determined their in vitro reactivation efficacy on inhibited human acetylcholinesterase, the crystal structure of two compounds in complex with the enzyme, their protective index on intoxicated mice, and their pharmacokinetics. We then evaluated their endothelial permeability coefficients with a human in vitro model. This study shed light on the structural restrains of new sugar oximes designed to reach the central nervous system through the glucose transporter located at the blood-brain barrier.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Aminolithiation–arylation consecutive cyclization of N-(2-fluorophenyl)methylaminoalkylstyryls giving aryl-substituted pyrido[1,2-b]isoquinolines

Aminolithiation–arylation tandem cyclization of N-(2-fluorophenyl)methylaminoalkylstyryls proceeded smoothly to give hexahydro-2H-pyrido[1,2-b]isoquinoline using a stoichiometric amount of n-BuLi with high trans selectivity. The arylation reaction was highly accelerated by the addition of HMPA. Both pyrido- and pyrrolo-[1,2-b]isoquinoline were successfully constructed by this tandem reaction.