79503-95-0

Upstream product

• 1002-28-4 3-hexyn-1-ol 
• 928-96-1 (Z)-3-Hexen-1-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 79503-96-1 1-selenophenylhex-3-ene 
• 5009-31-4 (Z)-1-Bromohex-3-ene 
• 21676-01-7 (Z)-3-hexenyl chloride 
• 22644-09-3 4Z,7Z-decadienal 
• 131102-92-6 (Z)-3-Benzyloxymethyl-non-6-enal 
• 131067-49-7 [(Z)-2-(2,2-Dimethoxy-ethyl)-oct-5-enyloxymethyl]-benzene 
• 131067-53-3 Acetic acid (Z)-3-benzyloxymethyl-non-6-enyl ester 
• 131067-52-2 (Z)-3-Benzyloxymethyl-non-6-en-1-ol 
• 21676-05-1 (3Z)-3-hexenyltriphenylphosphonium bromide 
• 106031-51-0 methyl (10E,12Z,15Z)-9-benzoyloxy octadecatrienoate 
• 92596-23-1 2-[(Z)-3-Isocyano-3-(toluene-4-sulfonyl)-non-6-enyl]-2-methyl-[1,3]dioxolane 
• 92596-20-8 1-((Z)-1-Isocyano-hept-4-ene-1-sulfonyl)-4-methyl-benzene 
• 4868-21-7 undec-8c-ene-2,5-dione 
• 488-10-8 cis-jasmone 

Relevant academic research and scientific papers

TASTE MODULATING ALDEHYDES

Aldehydes of formula (I) (X represents an alkyl or alkenyl group having up to 9 carbon atoms) for use in taste modulation and/or flavor compositions are provided. Specifically, the compounds of the presently disclosed subject matter provide effective and unexpected taste modulating properties. The taste modulation and/or flavor compositions can be incorporated into various consumer end products in particular in combination with high intensity sweeteners.

Messenger RNA for the delivery composition and method (by machine translation)

The present invention provides compositions comprising the lipid particles of encapsulated in mRNA molecular composition. Said composite particle comprising a cationic lipid, a non-cationic lipid and encapsulated in the lipid particles of the mRNA molecules in the lipid particle. The composition (for example) is used for the introduction of human subject suffering from a mRNA molecule, they are subject in said translation in order to produce the used to improve one or more of the symptoms of the disease polypeptide. The invention also provides for the preparation of said composition of the present invention a cationic lipid. (by machine translation)

COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA

The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.

COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA

The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.

OXIDIZED LIPID COMPOUNDS AND USES THEREOF

Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.

Regioselective oxidative cation-olefin cyclization of poly-enes: Catalyst turnover via hydride abstraction

Electrophilic P2Pt2+ complexes are shown to catalyze the regio- and diastereoselective oxidative cascade cyclization of poly-enes. The reactions are stereospecific with respect to the initiating alkenes geometry and suggest an all-chair, semiconcerted transition structure. Catalyst turnover after cyclization apparently occurs via β-hydride elimination and subsequent hydride abstraction (from P2Pt-H+) by added Trityl cation (in the form of trityl methyl ether or a resin version thereof) to regenerate the active P2Pt2+ state. One intriguing possibility is that the high regioselectivity observed in the β-H elimination is due to a regio-defining β-agostic resting state. Copyright

A new, simple synthesis of N-tosyl pyrrolidines and piperidines

Iodocyclization of unsaturated tosylamides promoted by Oxone oxidation of KI afforded, in good yields, N-tosyl iodopyrrolidines and piperidines. A new, simple method for the conversion of alcohols to tosylamides is presented. Georg Thieme Verlag Stuttgart.

Asymmetric total synthesis of (+)-exo-brevicomin based on enantioconvergent biocatalytic hydrolysis of an alkene-functionalized 2,3-disubstituted epoxide

A short total asymmetric synthesis of (+)-exo- and (-)-endo-brevicomin ((+)-exo-3 and (-)-endo-3), which are components of the attracting pheromone system of several bark-beetle species belonging to the genera Dendroctonus and Dryocoetes, was accomplished via a chemoenzymatic protocol. The key step consisted of biocatalytic hydrolysis by bacterial epoxide hydrolases of cis-configured 2,3-disubstituted oxiranes bearing olefinic side chains. This reaction proceeded in an enantioconvergent fashion, by affording a single enantiomeric vic-diol from the rac-epoxide in up to 92% ee and 83% isolated yield.

Enzyme-triggered enantioconvergent transformation of haloalkyl epoxides

Biocatalytic hydrolysis of 2,3-disubstituted rac-cis- and rac-trans-haloalkyl epoxides 1a-8a using the epoxide hydrolase activity of whole bacterial cells furnished the corresponding vicinal diols 1b-8b as intermediates; these (spontaneously) underwent ring closure to yield cyclic products 1c-6c through an enzyme-triggered cascade reaction. In particular, cis-configured substrates (1a, 3a, 5a, 7a) were transformed in an enantioconvergent fashion, which resulted in the formation of single stereoisomeric products in 100% des and up to 92% ees from the racemates.

Transition Metal-Catalyzed Intramolecular Cyclization of 1,5- And 1,6-Dienes via Direct Cleavage and Addition of the Carbon-Hydrogen Bond

Ruthenium- and rhodium-catalyzed intramolecular C-H/olefin coupling reactions of 1-(2-pyridyl)-, 1-(2-imidazolyl-, and 1-(2-oxazolyl)-1,5-dienes proceeded in a regiospecific manner to give 5-membered ring products. Their 1,6-diene analogues are also applicable to the cyclization reaction to give the corresponding 5- and 6-membered carbocycles. For the cyclization of the pyridine derivatives, [RhCl(PPh3)3] showed the highest catalytic activity with respect to efficiency and selectivity. When the imidazole derivatives were employed to the cyclization reaction, the combination of the rhodium(I) complex and the relatively sterically bulky phosphine (e.g., PCy3 and PPFOMe) was a quite effective catalyst system. In the case of the oxazoles, the ruthenium complex, [Ru(H)2(CO)(PPh3)3], showed the highest activity among the catalysts examined. These catalytic reactions usually proceed at 120°C. The [RhCl(PPh3)3]-catalyzed cyclization reaction of 2-[(1E)-4,4-dimethyl-1,5-hexadienyl]pyridine smoothly proceeded even at room temperature to give the corresponding cyclized product in 93% yield after 24 h. A hybrid catalyst system containing the rhodium(I) and both PPh3 and P(o-tolyl)3 had a slightly better catalytic activity compared with that of [RhCl(PPh3)3]. The intramolecular cyclization can be also applied to the C-H/CO/olefin coupling reactions. These carbonylation reactions gave the 5-membered ring ketones exclusively. The intramolecular C-H/olefin coupling reactions provide a new entry for constructing carbocyclic compounds from 1,n-dienes.