79510-57-9

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 100-52-7 benzaldehyde 
• 51978-94-0 (E)-3-methyl-4-nitro-5-styrylisoxazole 
• 123-54-6 acetylacetone 
• 53557-94-1 5-styryl-4-nitro-3-methylisoxazole 

Downstream Products

• 1242340-69-7 C₂₇H₂₂N₆O₇ 
• 1389313-02-3 C₁₉H₁₈N₆O₃S₂ 
• 1389313-10-3 C₄₉H₃₆Cl₂N₆O₃S₂ 
• 1389313-09-0 C₅₁H₄₂N₆O₅S₂ 
• 1389313-08-9 C₅₁H₄₂N₆O₃S₂ 
• 1389313-07-8 C₄₉H₃₈N₆O₅S₂ 
• 1389313-05-6 C₅₁H₄₂N₆O₃S₂ 
• 1389313-04-5 C₄₉H₃₆Cl₂N₆O₃S₂ 
• 1389313-03-4 C₄₉H₃₈N₆O₃S₂ 
• 1389313-11-4 C₄₉H₃₆Cl₂N₆O₃S₂ 
• 98239-45-3 5-[2-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-phenylethyl]-3-methyl-4-nitroisoxazole 
• 98239-35-1 5-[2-(3,5-dimethyl-1H-pyrazol-4-yl)-2-phenylethyl]-3-methyl-4-nitroisoxazole 
• 78636-44-9 5-[2-(3,5-dimethylisoxazol-5-yl)-2-phenylethyl]-3-methyl-4-nitroisoxazole 
• 51978-94-0 (E)-3-methyl-4-nitro-5-styrylisoxazole 

Relevant academic research and scientific papers

Synthesis of novel isoxazolyl bis-thiazolo[3,2-a]pyrimidines

A new synthetic strategy for the synthesis of novel 3-(3-(3-methyl-4- nitroisoxazol-5-yl)-2-phenyl-1-(5,7-diaryl-7H-thiazolo[3,2-a]pyrimidin-3-yl) propyl)-5,7-diaryl-7H-thiazolo[3,2-a] pyrimidines (7a-i) analogues is described. Reaction of 3-(2-(3-methyl-4-nitroisoxazole-5-yl)-1-phenylethyl)pentane-2,4- dione (3) with two moles of thiourea in presence of iodine and CuO afforded 4-(1-(2-aminothiazol-4-yl)-3-(3-methyl-4-nitroisoxazol-5-yl)-2-aryl propyl-thiazol-2-amine (5). Compound 5 on reaction with two moles of chalcone (6) furnished novel 3-(3-(3-methyl-4-nitroisoxazol-5-yl)-2-phenyl-1-(5,7-diaryl- 7H-thiazolo[3,2-a]pyrimidin-3-yl)propyl)-5,7-diaryl-7H-thiazolo[3,2-a] pyrimidines (7a-i).

A fast, highly efficient and green protocol for Michael addition of active methylene compounds to styrylisoxazoles using task-specific basic ionic liquid [bmIm]OH as catalyst and green solvent

A fast, highly efficient and green protocol for the Michael addition of active methylene compounds to styrylisoxazoles at room temperature has been investigated using task-specific basic ionic liquid, 3-butyl-1-methyl imidazolium hydroxide, [bmIm]OH, as a

Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N- oxides

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.

Multicomponent synthesis of 3-heteroarylpropionic acids

(Chemical Equation Presented) A four component one-pot procedure (4-MC) was developed to assemble 3-heteroarylpropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chr

Multicomponent synthesis of spiroisoxazolines

A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

Michael additions on isoxazole derivatives under solvent-free conditions

Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com

The reactivity of 3-methyl-4-nitro-5-styrylisoxazole with some bis-enolisable ketones

The expected Michael adducts and spiroisoxazolines are obtained from the reaction between 3-methyl-4-nitro-5-styrylisoxazole and bis-enolisable ketones. Contrary to reported data, Michael adducts are obtained in good yields only when a substoichiometric amount of base is used, whereas spiroisoxazolines were obtained as the major product when the base is present in a large excess.

Chemistry of Heterocylces: Part VIII - Synthesis of Isoxazolylethylpyrazoles

The base-catalysed addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (II) leads to the Michael adducts 3-pentane-2,4-diones (III).These β-diketones (III) undergo cyclization with hydrazine sulphate and phenylhydrazine to furnish pyrazoles (IV) and N-phenylpyrazoles (V), respectively.

Ethylene-diheterocycles: Part I - Synthesis of 5--3-methyl-4-nitroisoxazoles

Michael addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (I) in triethylamine leads to 3--2,4-pentanediones (II).The pentanediones (II) undergo cyclisation with hydroxylamine to give 5-ω

Attempted Heterocyclization of 2-Substituted 1,3-Diketones in Presence of Ethylenediamine

3-pentane-2,4-diones (II) when treated with ethylenediamine undergo retro Michael reaction to give 3-methyl-4-nitro-5-styrylisoxazoles (I).