79526-13-9Relevant academic research and scientific papers
Reactions of polyfluoro-2-alkynoic acids with bifunctional hetero nucleophiles leading to polyfluoroalkylated heterocycles
Yamanaka, Hiroki,Tamura, Kazushige,Funabiki, Kazumasa,Fukunishi, Koushi,Ishihara, Takashi
, p. 177 - 190 (1992)
Polyfluoro-2-alkynoic acids, Rf-CC-COOH (Rf = HCF2, CF3, H(CF2)3), readily undergo tandem intermolecular-intramolecular Michael addition with bifunctional hetero nucleophiles, HX(CH2)nYH (X, Y = S, O; n = 2, 3), to give 2-polyfluoroalkylated 1,3-diheterocyclic compounds in good to excellent yields.
