Journal of Fluorine Chemistry p. 177 - 190 (1992)
Update date:2022-07-31
Topics:
Yamanaka, Hiroki
Tamura, Kazushige
Funabiki, Kazumasa
Fukunishi, Koushi
Ishihara, Takashi
Polyfluoro-2-alkynoic acids, Rf-C<*>C-COOH (Rf = HCF2, CF3, H(CF2)3), readily undergo tandem intermolecular-intramolecular Michael addition with bifunctional hetero nucleophiles, HX(CH2)nYH (X, Y = S, O; n = 2, 3), to give 2-polyfluoroalkylated 1,3-diheterocyclic compounds in good to excellent yields.
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Doi:10.1021/ja00366a027
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