Reactions of polyfluoro-2-alkynoic acids with bifunctional hetero nucleophiles leading to polyfluoroalkylated heterocycles

DOI: 10.1016/S0022-1139(00)82830-4

Source and publish data:

Journal of Fluorine Chemistry p. 177 - 190 (1992)

Update date:2022-07-31

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Authors:

Yamanaka, Hiroki

Tamura, Kazushige

Funabiki, Kazumasa

Fukunishi, Koushi

Ishihara, Takashi

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Article abstract of DOI:10.1016/S0022-1139(00)82830-4

Polyfluoro-2-alkynoic acids, R_f-C<*>C-COOH (R_f = HCF2, CF3, H(CF2)3), readily undergo tandem intermolecular-intramolecular Michael addition with bifunctional hetero nucleophiles, HX(CH2)_nYH (X, Y = S, O; n = 2, 3), to give 2-polyfluoroalkylated 1,3-diheterocyclic compounds in good to excellent yields.

Full text of DOI:10.1016/S0022-1139(00)82830-4

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