79531-82-1

Basic information

• Product Name: 2-(thiophen-2-ylmethylidene)hydrazinecarboxamide
• CAS NO: 79531-82-1
• Molecular Formula: C₆H₇N₃OS
• Molecular Weight: 169.2043
• Mol File: 79531-82-1.mol
• Article Data: 2

Chemical Properties

• Density: 1.42g/cm³
• Refractive Index: 1.671
• CAS DataBase Reference: 2-(thiophen-2-ylmethylidene)hydrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(thiophen-2-ylmethylidene)hydrazinecarboxamide(79531-82-1)
• EPA Substance Registry System: 2-(thiophen-2-ylmethylidene)hydrazinecarboxamide(79531-82-1)

Safety Data

• Hazardous Substances Data: 79531-82-1(Hazardous Substances Data)

Usage

Derivative of hydrazinecarboxamide

Contains a thiophene ring and a hydrazine group

Potential applications

Medicinal chemistry, development of novel pharmaceuticals

Unique structural features

Interesting candidate for further investigation as a potential drug candidate

Properties and reactivity

May be useful in other chemical processes and applications

Further research

May reveal more about specific properties and potential uses of this chemical.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 563-41-7 semicarbazide hydrochloride 

Downstream Products

• 27049-71-4 5-(thiophen-2-yl)-1,3,4-oxadiazol-2-amine 
• 1290545-12-8 [(benzyl)3tin(IV)(thiophene-2-carboxaldehyde semicarbazone(-H))] 
• 173917-25-4 Sb(C₆H₅)2C₇H₈N₃O₂ 
• 149538-42-1 (C₆H₅)3Sn(C₄H₃SCHNNCONH₂) 

Relevant articles and documents

Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Anti-bacterial Agents

Objective: The objective of the present study was to prepare the 5-substituted 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole derivatives and evaluate their potential anticancer, antibac-terial and antifungal activities. Methods: Twenty-seven derivatives were synthesized by iodine-mediated cyclization of semicarba-zones or thiosemicarbazones obtained from condensation of semicarbazide or thiosemicarbazide and aldehydes. The structures were confirmed by1H-NMR,13C-NMR and MS spectra. The antibacterial and antifungal activities were evaluated by diffusion method and the anticancer activities were evaluated by MTT assay. Results: Twenty-seven derivatives have been synthesized in moderate to good yields. A number of derivatives exhibited potential antibacterial, antifungal and anticancer activities. Conclusion: Compounds (1b, 1e and 1g) showed antibacterial activity against Streptococcus faecal-is, MSSA and MRSA with MIC value ranging between 4 to 64 μg/mL. Compound (2g) showed anti-fungal activity against Candida albicans (8 μg/mL) and Aspergillus niger (64 μg/mL). Compound (1o) exhibited high cytotoxic activity against HepG2 cell line (IC50 value 8.6 μM) which is compara-ble to the activity of paclitaxel, and is non-toxic on LLC-PK1 normal cell line. The structure activity relationship and molecular docking study of the synthesized compounds have also been reported.