79532-22-2

Upstream product

• 75-16-1 methylmagnesium bromide 
• 66162-60-5 (3,4,5-trimethoxyphenyl)acetic acid ethyl ester 
• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 
• 2989-06-2 methyl 2-(3,4,5-trimethoxyphenyl)acetate 

Downstream Products

• 79532-24-4 N-(3,4,5-trimethoxy-α,α-dimethylphenethyl)formamide 
• 79532-23-3 3,4-dihydro-6,7,8-trimethoxy-3,3-dimethylisoquinoline, hydrochloride 

Relevant academic research and scientific papers

Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.

Bronchodilators. 3,4,5-trihydroxyphenylethanol amines

In an attempt to further define the effect of ring substitution on the β-adrenergic activity of phenylethanol amines, a group of 3,4,5-trihydroxy-substituted N-alkylphenylethanol amines were prepared. The synthesis of these compounds and their effect on b