79533-04-3Relevant academic research and scientific papers
Pd-catalyzed Suzuki-Miyaura cross-coupling reactions between sulfamates and potassium Boc-protected aminomethyltrifluoroborates
Molander, Gary A.,Shin, Inji
, p. 2534 - 2537 (2013/06/27)
Sulfamates were studied as the electrophilic partners in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with potassium Boc-protected primary and secondary aminomethyltrifluoroborates. A broad range of substrates was successfully coupled to provide the desired products. Complex molecules containing a new carbon-carbon bond and an aminomethyl moiety could be prepared through this developed method.
Suzuki-Miyaura cross-coupling reactions of potassium boc-protected aminomethyltrifluoroborate with aryl and hetaryl mesylates
Molander, Gary A.,Shin, Inji
supporting information; experimental part, p. 3138 - 3141 (2012/08/07)
Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions were studied with potassium Boc-protected aminomethyltrifluoroborate through C-O activation of various mesylate derivatives to afford the corresponding products in moderate to good yields.
Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction
Buckley, Dennis L.,Van Molle, Inge,Gareiss, Peter C.,Tae, Hyun Seop,Michel, Julien,Noblin, Devin J.,Jorgensen, William L.,Ciulli, Alessio,Crews, Craig M.
, p. 4465 - 4468 (2012/04/23)
E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the development of small-molecule inhibitors has proven extrao
Synthesis and Suzuki-Miyaura cross-coupling reactions of potassium Boc-protected aminomethyltrifluoroborate with aryl and hetaryl halides
Molander, Gary A.,Shin, Inji
, p. 3956 - 3959 (2011/10/03)
Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.
Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group
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, (2008/06/13)
Compounds of the formula STR1 in which the index n represents an integer of from 1 to 4, the index m represents 0 or 1, X represents oxygen, sulphur or the group --NH--, W represents a group --CO--, --CO--NHSO2 -- or --SO2 NH--CO--, or X-W together represent a group --CO-- or --CO--NHSO2 --, A represents optionally substituted phenylene, thienylene or furylene, Z represents oxygen or sulphur, Y represents lower alkylene, the index k represents the value 1 or 2, R4 represents hydrogen, an optionally substituted lower aliphatic or cycloaliphatic radical or acyl, R1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH2 --R2 in which R2 represents a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, and R3 represents hydrogen or methoxy, and in which the carboxyl groups are optionally esterified in a form that can be split under physiological conditions, and salts of such compounds having salt-forming groups, are obtained by liberating the functional group(s) in a compound of the formula I in which at least one of the functional groups present is protected. The compounds are effective in vitro and in vivo against gram-positive and gram-negative bacteria and cocci.
