79560-72-8

Upstream product

• 33829-00-4 3-[(4-bromophenyl)imino]-1,3-dihydro-2H-indol-2-one 
• 2646-31-3 4-(p-bromophenyl)thiosemicarbazide 
• 91-56-5 indole-2,3-dione 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 79560-87-5 C₂₀H₂₀BrN₅O₂S 
• 79560-82-0 C₂₁H₂₂BrN₅OS 
• 1421488-35-8 C₁₅H₁₁BrN₄OS 

Relevant academic research and scientific papers

Aqua mediated one pot facile synthesis of novel thioxo-1,2,4-triazin-5(2H)- one and [1,2,4] triazino[5,6-b]indole derivatives and their biological activities

Rapid and highly efficient one pot green chemical synthesis of substituted 6-(2-aminophenyl)-4-(4-substitutedphenyl)-3-thioxo-3,4-dihydro-1,2, 4-triazin-5(2H)-one and 8-substituted-3,5-dihydro-2H-[1,2,4]triazino[5,6-b] indole is carried out in aqueous medium under microwave irradiation. Improved synthesis of potent bioactive Schiff and N-Mannich bases of hexahydro-1H-indole- 2,3-dione is also reported. The title compounds are easily accessible by various approaches; even waste free approaches have been developed. The operational simplicity, environmentally benign conditions and high yield achieved in a very short reaction time are major benefits that meet the requirements of green production, including saving energy and high efficiency. The results obtained under microwaves are compared with that of conventional heating. Structural assignments are based on spectroscopic data. Compounds have also been screened for antibacterial and antifungal activities.

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

Synthesis and fungicidal activity of some 2-arylamino-1,3,4- thiadiazino[6,5-b] indoles and 2-aryl-1,3,4-oxadiazolo-[2,3-c]- 1,2,4- triazino [5,6-b] indoles

2-Arylamino-1,3,4-thiadiazino [6,5-b] indoles 3 and 2-aryl-1,3,4- oxadiazolo [2,3-c] [1,2,4] triazino [5,6-b] indoles 6 have been synthesized by cyclization of isatin-3-(arylthiosemicarbazones) and isatin-3-(5-aryl- 1,3,4-oxadiazol-2-yl) hydrazones with conc H2SO4 and screened for their fungicidal activity.

Syntheses of some substituted isatin-β-thiosemicarbazones and isatin-β-hydrazonothiazoline derivatives as potential antiviral and antimicrobial agents

A series of isatin-β-thioxemicarbazones and isatin-β-hydrazonothiazolines was synthesized by condensation of various isatin derivatives with N4-substituted-3-thiosemicarbazides and cyclization of the products by phenacyl bromides. The products

Reactions of 3-Arylimino-2-Indolinones with p-Substituted Phenylthiosemicarbazides

3-Arylimino-2-indolinones (II) have been prepared by the condensation of isatins (I) with anilines.Reactions of II with p-substituted phenylthiosemicarbazides have resulted (in every instance) in the displacement of arylimino groups by the phenylthiosemic