79562-60-0

Upstream product

• 27151-65-1 3-methyl-1,5-pentanedioic acid monomethyl ester 
• 79562-58-6 2,3,5,6,7,8-Hexahydro-2-hydroxy-1-methoxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 79562-57-5 trans-2-Bromo-2,3,5,6,7,8-hexahydro-1-hydroxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 77198-70-0 2,3,5,6,7,8-Hexahydro-2(R)-hydroxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 93454-30-9 5,6,7,8-Tetrahydro-6-methyl-8-oxo-3H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 79562-58-6 cis-2,3,5,6,7,8-Hexahydro-2-hydroxy-1-methoxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 100-39-0 benzyl bromide 
• 79562-59-7 cis-2,3,5,6,7,8-Hexahydro-2-<(methylsulfonyl)oxy>-1-methoxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 79562-59-7 2,3,5,6,7,8-Hexahydro-2-<(methylsulfonyl)oxy>-1-methoxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 
• 65481-20-1 Dimethyl 2(R)-acetoxy-2,3-dihydro-5-(3-carbomethoxy-2-methylpropyl)-1H-pyrrolizine-6,7-dicarboxylate 
• 65481-19-8 Dimethyl 2,3-dihydro-2(R)-hydroxy-5-(3-carbomethoxy-2-methylpropyl)-1H-pyrrolizine-6,7-dicarboxylate 
• 65481-22-3 Dimethyl 2,3,5,6,7,8-hexahydro-2(R)-hydroxy-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-7,9-dicarboxylate 
• 79562-55-3 N-(4-Carbomethoxy-3-methylbutyroyl)-4-acetoxy-L-proline 
• 77198-71-1 2,3,5,6,7,8-Hexahydro-2(R)-<(methylsulfonyl)oxy>-6-methyl-8-oxo-1H-pyrrolo<1,2-a>indole-9-carboxylic acid 

Downstream Products

• 79562-61-1 Benzyl 2,3-Dihydro-8-hydroxy-2-<(methylsulfonyl)oxy>-1-methoxy-6-methyl-1H-pyrrolo<1,2-a>indole-9-carboxylate 

Relevant academic research and scientific papers

Total Synthesis of a Mitosene

The total synthesis of a mitosene (a chemical degradation product of mitomycin C) is described.The synthesis begins with hydroxyproline and uses a Huisgen pyrrole synthesis to form a pyrrolizidine system.The carbocyclic ring is made through Dieckmann cycl

THE TOTAL SYNTHESIS OF A MITOSENE

The conversion of L-hydroxyproline to a mitosene (degradation product of a mitomycin) is described.The synthesis involves 19 steps and the key stereochemical feature arises from an unusual cis opening of an epoxide.The synthetic product, 1-methoxy-2,7-diamino-mitosene is shown to be identical with the trans isomer obtained from acid-catalyzed methanolysis of mitomycin C.