79580-28-2 Usage
Uses
Used in Neurological Research:
Brevetoxin B is used as a research tool for studying the function and regulation of voltage-gated sodium channels in neurons. Its ability to irreversibly open these channels at more negative potentials than normal allows researchers to investigate the role of these channels in neuronal excitability and neurotransmission.
Used in Environmental Monitoring:
Brevetoxin B is used as a biomarker for detecting the presence of harmful algal blooms caused by Karenia species and other dinoflagellates. Monitoring the levels of this neurotoxin in water samples can help assess the risk of neurotoxic shellfish poisoning and inform public health and safety measures.
Used in Drug Development:
Brevetoxin B has potential applications in the development of drugs targeting voltage-gated sodium channels for the treatment of neurological disorders. Its unique mechanism of action may provide insights into the design of novel therapeutic agents with improved efficacy and selectivity.
Used in Toxicology Studies:
Brevetoxin B is used in toxicology studies to investigate the effects of neurotoxins on the nervous system and to develop methods for detecting and mitigating their harmful effects. Understanding the molecular mechanisms underlying the toxicity of Brevetoxin B can contribute to the development of antidotes and countermeasures against exposure to this and other similar toxins.
Check Digit Verification of cas no
The CAS Registry Mumber 79580-28-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,5,8 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 79580-28:
(7*7)+(6*9)+(5*5)+(4*8)+(3*0)+(2*2)+(1*8)=172
172 % 10 = 2
So 79580-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-
79580-28-2Relevant academic research and scientific papers
Total synthesis of brevetoxin B
Kadota, Isao,Takamura, Hiroyoshi,Nishii, Hiroki,Yamamoto, Yoshinori
, p. 9246 - 9250 (2007/10/03)
The convergent total synthesis of brevetoxin B (1) has been achieved. The intramolecular allylation of the O,S-acetal 20, prepared from the α-chlorosulfide 17 and the alcohol 5, was carried out using AgOTf as a Lewis acid to give the diene 21, predominant
Total synthesis of brevetoxin B. 3. Final strategy and completion
Nicolaou,Rutjes,Theodorakis,Tiebes,Sato,Untersteller
, p. 10252 - 10263 (2007/10/03)
The final strategy for the total synthesis of brevetoxin B (1) according to the retrosynthetic analysis shown in Scheme 1 is described. Starting with the tetracyclic ring system 8 [DEFG], the construction of the C ring was accomplished via an intramolecul
