796046-85-0Relevant academic research and scientific papers
Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same
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Page/Page column 15, (2009/03/07)
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45
RHODANDSE DERIVARIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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Page/Page column 20, (2010/11/28)
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTPlB, Prl-3, LAR, CD45
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors
Ahn, Jin Hee,Kim, Seung Jun,Park, Woul Seong,Cho, Sung Yun,Ha, Jae Du,Kim, Sung Soo,Kang, Seung Kyu,Jeong, Dae Gwin,Jung, Suk-Kyeong,Lee, Sang-Hyeup,Kim, Hwan Mook,Park, Song Kyu,Lee, Ki Ho,Lee, Chang Woo,Ryu, Seong Eon,Choi, Joong-Kwon
, p. 2996 - 2999 (2008/09/20)
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.
Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation
Chen, Han,Fan, Yun-Hua,Natarajan, Amarnath,Guo, Yuhong,Iyasere, Julia,Harbinski, Fred,Luus, Lia,Christ, William,Aktas, Huseyin,Halperin, Jose A.
, p. 5401 - 5405 (2007/10/03)
A series of 2′-benzyloxy-5′-substituted-5-benzylidene- thiazolidine-2,4-thione and -dione derivatives was synthesized and evaluated as inhibitors of translation initiation. In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2′-benzyloxy- 5′-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiation specific assays. Several candidates of the 5-benzylidene-thiazolidine-2,4-diones (3c, 3d, and 3f) and -thiones (2b, 2e, and 2j), inhibit cell growth with low μM GI50 mediated by inhibition of translation initiation, which involves partial depletion of intracellular Ca2+ stores and strong phosphorylation of eIF2Iα.
