79607-10-6Relevant academic research and scientific papers
Synthesis of imidazoles via hetero-cope rearrangements
Lantos,Zhang,Shui,Eggleston
, p. 7092 - 7095 (1993)
A novel synthetic approach to heterocycles containing the imidazole moiety based on the multihetero-Cope rearrangement is described. Oximes are reacted with benzenecarboximidoyl chlorides 4 affording adducts that readily undergo the hetero-Cope rearrangement at slightly elevated temperatures. Acid treatment of the resulting amidines 8 provides imidazoles in very high yields.
