79607-25-3

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 55668-30-9 2-aminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester 
• 118-48-9 isatoic anhydride 
• 91-56-5 indole-2,3-dione 
• 61429-66-1 ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate 

Downstream Products

• 50593-13-0 4-chloro-2-phenyl-quinoline-3-carboxylic acid ethyl ester 
• 1337542-89-8 ethyl 4-amino-2-phenylquinoline-3-carboxylate 

Relevant academic research and scientific papers

Eco-friendly decarboxylative cyclization in water: Practical access to the anti-malarial 4-quinolones

An environmentally benign decarboxylative cyclization in water has been developed to synthesize 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds. Isatins are also compatible for the reaction to generate 4-quinolones in the presence of TBHP in DMSO. This protocol provides excellent yields under mild conditions for a broad scope of 4-quinolones, and has good functional group tolerance. Only un-harmful carbon dioxide and water are released in this procedure. Moreover, the newly synthesized products have also been selected for anti-malarial examination against the chloroquine drug-sensitive Plasmodium falciparum 3D7 strain. 3u is found to display excellent anti-malarial activity with an IC50 value of 33 nM.

COMPOUND, ORGANIC OPTOELECTRIC DEVICE AND DISPLAY DEVICE

The present invention relates to a compound represented by chemical formula 1, an organic optoelectronic device comprising the same, and a display device comprising the organic optoelectronic device. In chemical formula 1, the definitions of X^1 to X^6, L

Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents

Substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized. The results of preliminary screening revealed that these compounds are potent in killing solid tumor cancers.

Reactions of N-hydroxysuccinimide esters of anthranilic acids with anions of β-keto esters. A new route to 4-oxo-3-quinolinecarboxylic acid derivatives

A new approach for the synthesis of 4-oxo-3-quinolinecarboxylic acid derivatives is described. This methodology involves the C-acylation of the anions of appropriate β-keto esters with novel N-hydroxysuccinimide esters of anthranilic acids. The intermedia

A Nitroketene to Nitrile Oxide Transformation

2,3-Dihydropyrrole-2,3-diones 1 thermally extrude CO, giving imidoylketenes 2, which cyclise efficiently to 4-quinolones 3; however, the analogous nitro(imidoyl)ketene 5 eliminates CO2 and rearranges to the 3-oximino-3H-indole 9, presumably via an imidoyl