796105-41-4Relevant academic research and scientific papers
Total synthesis of (+)-tanikolide, a toxic and antifungal δ-lactone, utilizing bromoalkene intermediates conveniently synthesized from vicinal dibromoalkane by regioselective elimination
Ohgiya, Tadaaki,Nishiyama, Shigeru
, p. 8273 - 8275 (2004)
Stereoselective total synthesis of (+)-tanikolide, a bioactive δ-lactone marine natural product, was successfully accomplished by using regioselective HBr elimination reaction of 3-acyloxy-1,2-dibromoalkanes, Pd-mediated coupling reaction, and the Sharpless asymmetric epoxidation as key steps.
Total synthesis of (+)-tanikolide, using regioselective elimination of a vicinal dibromoalkane
Ohgiya, Tadaaki,Nakamura, Kensuke,Nishiyama, Shigeru
, p. 1549 - 1554 (2007/10/03)
Total synthesis of (+)-tanikolide, a bioactive δ-lactone of marine origin, was successfully accomplished by utilizing a bromoalkene derivative conveniently synthesized from the corresponding 1-acyloxy-2,3-dibromoalkane by the regioselective and mild HBr-elimination reaction, along with the Pd-mediated C-C coupling reaction and the Sharpless asymmetric epoxidation as key steps.
