79611-67-9Relevant academic research and scientific papers
Synthesis of (Z)-α-Trifluoromethyl Alkenyl Triflate: A Scaffold for Diverse Trifluoromethylated Species
Zhao, Yilong,Zhou, Yuhan,Liu, Juan,Yang, Dongmei,Tao, Liang,Liu, Yang,Dong, Xiaoliang,Liu, Jianhui,Qu, Jingping
, p. 4797 - 4806 (2016/07/06)
An efficient method for the synthesis of (Z)-selective α-trifluoromethyl alkenyl triflates is described. As an important fluorinated building block, it is utilized successfully for the synthesis of various trifluoromethyl derivatives such as diarylethylen
Copper(i)-catalyzed wittig olefination reactions of N-tosylhydrazones with trifluoromethylketones
Sha, Qiang,Wei, Yunyang
, p. 131 - 134 (2014/01/23)
Cuprous iodide-catalyzed Wittig olefination reactions of N-tosylhydrazones with trifluoromethylketones are reported. This procedure provides an efficient method for the synthesis of various trifluoromethyl-substituted alkenes in moderate to good yields (up to 89 % yield) and good stereoselectivity (up to 93 % E-selectivity). To the best of our knowledge, it is the first report of a Wittig reaction of N-tosylhydrazones with ketones. Copyright
One-pot multistep synthesis of trisubstituted alkenes from N -tosylhydrazones and alcohols
Sha, Qiang,Wei, Yunyang
supporting information, p. 2353 - 2361 (2014/11/08)
A one-pot procedure for the synthesis of trisubstituted alkenes from N-tosylhydrazones and alcohols is reported. This procedure combines the aerobic oxidation reaction and Wittig reaction in one pot, which avoids using of environmentally toxic oxidants and isolation of the intermediates. The simple procedure makes it very attractive for the synthesis of trisubstituted alkenes when alcohols are used as starting materials. A variety of trisubstituted alkenes as well as trifluoromethyl-substituted alkenes were obtained in moderate to good yields (up to 84%) with good E-selectivity (up to 99%). Georg Thieme Verlag Stuttgart.New York.
