79613-17-5Relevant academic research and scientific papers
Synthesis of novel benzimidazolyl-substituted acrylonitriles and amidino-substituted benzimidazo[1,2-a]quinolines
Hranjec, Marijana,Karminski-Zamola, Grace
, p. 1817 - 1828 (2007)
A series of novel benzimidazole derivatives 3-10 were synthesized. Benzimidazolyl-substituted acrylonitriles 3 and 4 underwent a photochemical dehydrocyclization reaction to give the corresponding mono- and dicyano-substituted benzimidazo[1,2-a] quinoline
Synthesis, computational analysis, and antiproliferative activity of novel benzimidazole acrylonitriles as tubulin polymerization inhibitors: Part 2
Be?, Anja,Daelemans, Dirk,Hok, Lucija,Hranjec, Marijana,Persoons, Leentje,Vanstreels, Els,Vianello, Robert
, (2021/11/01)
We used classical linear and microwave-assisted synthesis methods to prepare novel N-substituted, benzimidazole-derived acrylonitriles with antiproliferative activity against several cancer cells in vitro. The most potent systems showed pronounced activit
Knoevenagel condensation reaction using ionic liquid [ADPQ][CF3SO3] as green and reusable catalyst
Gao, Xiaochong,Gao, Can,Gao, Ruichang
, p. 2145 - 2148 (2015/11/28)
Knoevenagel condensation reaction of aromatic aldehydes with some active methylene compounds proceeded efficiently without solvent using ionic liquids as catalyst. The experimental results show that these ionic liquids have good catalytic activities to th
Synthesis of Polyazaheterocycles by Michael Addition of CH Acids to α,β-Unsaturated Nitriles. Synthesis of Pyridobenzimidazole and Pyrimidopyridobenzimidazole Derivatives
Bogdanowicz-Szwed, Krystyna,Czarny, Agnieszka
, p. 279 - 282 (2007/10/02)
Addition of 1H-benzimidazole-2-carbonitrile (1) to arylidenemalononitrile (2) gave 1-amino-3-aryl pyridobenzimidazole-2,4-dicarbonitrile (3), 2-aryl-benzimidazole (4) and 1H-benzimidazole-2-acetonitrile, α-(arylmethylene) (5).Compounds (3) reacted with formamide yielding 4-amino-5-aryl pyrimidopyridobenzimidazole (6).
