79622-11-0

Usage

Uses

Used in Bioconjugation:
m-PEG8-Tos is used as a bioconjugation agent for attaching biomolecules to other molecules or surfaces. The tosyl group facilitates nucleophilic substitution reactions, allowing for the efficient coupling of the PEG spacer to target molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG8-Tos is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG spacer can help reduce the immunogenicity and non-specific interactions of drug molecules, enhancing their therapeutic efficacy.
Used in Polymer Science:
m-PEG8-Tos is utilized as a building block in the synthesis of various polymers and copolymers. The PEG-based structure allows for the creation of materials with tailored properties, such as hydrophilicity, biocompatibility, and self-assembly behavior, which can be applied in areas like hydrogels, micelles, and nanoparticles.
Used in Chemical Synthesis:
In organic synthesis, m-PEG8-Tos serves as a versatile intermediate for the preparation of a wide range of PEGylated compounds. The tosyl group's reactivity in nucleophilic substitution reactions enables the synthesis of various functionalized PEG derivatives for use in research and industry.

Upstream product

• 112-35-6 triethylene glucol monomethyl ether 
• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 
• 74654-05-0 8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane 
• 4437-01-8 3,6,9,12,15,18,21-heptaoxadocosan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 208987-04-6 azidoheptaethylene glycol methyl ether 
• 854601-70-0 (5α,6α)-17-allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy)-4,5-epoxymorphinan-3,14-diol 
• 1354744-91-4 naloxegol oxalate 
• 1136742-88-5 C₂₁H₃₇NO₈ 
• 134874-49-0 alpha-methoxy-omega-mercapto-hepta(ethylene glycol) 

Relevant academic research and scientific papers

Synthesis and self-assembly of rod-coil molecules with n-shaped rod building block

The rod-coil molecules with n-shaped rod building block, consisting of an anthracene unit and two biphenyl groups linked together with acetylenyl bonds at the 1,8-position of anthracene as a rigid rod segment, and the alkyl or alkyloxy chains with various

Construction of Supramolecular Assemblies from Self-Organization of Amphiphilic Molecular Isomers

Amphiphilic coil-rod-coil molecules, incorporating flexible and rigid blocks, have a strong affinity to self-organize into various supramolecular aggregates in bulk and in aqueous solutions. In this paper, we report the self-assembling behavior of amphiphilic coil-rod-coil molecular isomers. These molecules consist of biphenyl and phenyl units connected by ether bonds as the rod segment, and poly(ethylene oxide) (PEO) with a degree of polymerization of 7 and 12 as the flexible chains. Their aggregation behavior was investigated by differential scanning calorimetry, thermal optical polarized microscopy, small-angle X-ray scattering spectroscopy, and transmission electron microscopy. The results imply that the molecular structure of the rod building block and the length of the PEO chains dramatically influence the creation of supramolecular aggregates in bulk and in aqueous solutions. In the bulk state, these molecules self-organize into a hexagonal perforated lamellar and an oblique columnar structure, respectively, depending on the sequence of the rod building block. In aqueous solution, the molecule with a linear rod segment self-assembles into sheet-like nanoribbons. In contrast, its isomer, with a rod building block substituted at the meta-position of the aryl group, self-organizes into nanofibers. This is achieved through the control of the non-covalent interactions of the rod building blocks.

Novel amphiphilic PEO-grafted cardo poly(aryl ether sulfone) copolymer: Synthesis, characterization and antifouling performance

A series of comb-like amphiphilic copolymers (PES-g-PEO) were synthesized through grafting poly(ethylene oxide) (PEO) to cardo poly(aryl ether sulfone) (PES-NH) backbone. By controlling the ratios of PEO and cardo poly(aryl ether sulfone), amphiphilic cop

Lactone Backbone Density in Rigid Electron-Deficient Semiconducting Polymers Enabling High n-type Organic Thermoelectric Performance

Three lactone-based rigid semiconducting polymers were designed to overcome major limitations in the development of n-type organic thermoelectrics, namely electrical conductivity and air stability. Experimental and theoretical investigations demonstrated that increasing the lactone group density by increasing the benzene content from 0 % benzene (P-0), to 50 % (P-50), and 75 % (P-75) resulted in progressively larger electron affinities (up to 4.37 eV), suggesting a more favorable doping process, when employing (N-DMBI) as the dopant. Larger polaron delocalization was also evident, due to the more planarized conformation, which is proposed to lead to a lower hopping energy barrier. As a consequence, the electrical conductivity increased by three orders of magnitude, to achieve values of up to 12 S cm and Power factors of 13.2 μWm?1 K?2 were thereby enabled. These findings present new insights into material design guidelines for the future development of air stable n-type organic thermoelectrics.

n-Type Rigid Semiconducting Polymers Bearing Oligo(Ethylene Glycol) Side Chains for High-Performance Organic Electrochemical Transistors

N-type conjugated polymers as the semiconducting component of organic electrochemical transistors (OECTs) are still undeveloped with respect to their p-type counterparts. Herein, we report two rigid n-type conjugated polymers bearing oligo(ethylene glycol

Surfactants and formulations

A herbicidal composition is provided comprising an aqueous solution of N-phosphonomethylglycine, predominantly in the form of the potassium salt thereof, at a concentration of at least 300 g a.e./l of the composition; and a surfactant component in solutio

Method for catalyzing green cyanation of halogenated aromatic hydrocarbons by supported Pd complex

The invention provides a method for catalyzing green cyanation of halogenated aromatic hydrocarbons by a supported Pd complex and belongs to the technical field of chemical engineering and catalysis.According to the method disclosed by the invention, a se

AN IMPROVED PROCESS FOR THE PREPARATION OF (5Α,6Α)-17-ALLYL-6-(2,5,8,11,14,17,20- HEPTAOXADOCOSAN-22-YLOXY)-4,5-EPOXYMORPHINAN-3,14-DIOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved process for the preparation of (5α, 6α)-17-allyl-6-(2, 5, 8, 11, 14, 17, 20- heptaoxadocosan-22-yloxy)-4, 5-epoxymorphinan-3, 14-diol which is represented by the following structural formula-1 or its pharmaceut

Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with 19F Magnetic Resonance

Monitoring a drug-delivery system with an imaging modality is of great importance for detailed understanding of drug-delivery processes and for achieving optimal therapeutic effects. Here, novel fluorinated self-assembled dendrimers with a single 19

Thermoresponsive Corannulene

We demonstrate herein that corannulene, a bowl-shaped polycyclic aromatic hydrocarbon, can assemble into larger supramolecular structures in water through a change in the solution temperature. This property is invoked through a simple five-fold symmetric