854601-70-0

Usage

Uses

Used in Pharmaceutical Industry:
Naloxegol is used as a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It works by blocking the peripheral effects of opioids on the gastrointestinal tract, thereby reducing constipation without affecting the central nervous system's pain relief properties. This selective action makes it a valuable therapeutic option for patients requiring long-term opioid therapy for chronic pain management.

Upstream product

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• 112-35-6 triethylene glucol monomethyl ether 
• 104518-25-4 22-bromo-2,5,8,11,14,17,20-heptaoxadocosane 
• 854601-63-1 (4R,4aS,7aR,12bS)-3-allyl-9-((2-methoxyethoxy)methoxy)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol 

Downstream Products

• 1354744-91-4 naloxegol oxalate 

Relevant academic research and scientific papers

Naloxegol Oxalate and Solid Dispersion thereof

The present invention relates to solid dispersion of Naloxegol oxalate. Further, the present invention relates to an improved process for Naloxegol oxalate and intermediates thereof.

AN IMPROVED PROCESS FOR THE PREPARATION OF (5Α,6Α)-17-ALLYL-6-(2,5,8,11,14,17,20- HEPTAOXADOCOSAN-22-YLOXY)-4,5-EPOXYMORPHINAN-3,14-DIOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved process for the preparation of (5α, 6α)-17-allyl-6-(2, 5, 8, 11, 14, 17, 20- heptaoxadocosan-22-yloxy)-4, 5-epoxymorphinan-3, 14-diol which is represented by the following structural formula-1 or its pharmaceut

NALOXEGOL OXALATE AND SOLID DISPERSION THEREOF

The present invention relates to solid dispersion of Naloxegol oxalate. Further, the present invention relates to an improved process for Naloxegol oxalate and intermediates thereof.