79636-94-5

Basic information

• Product Name: 5-BROMO-2-ETHOXYBENZALDEHYDE
• Synonyms: AURORA 10667;ASISCHEM R27959;5-BROMO-2-ETHOXYBENZALDEHYDE;AKOS B005861;AKOS BBS-00008217;5-Bromo-2-ethoxybenzaldehyde,98%;515752_ALDRICH;NSC157341
• CAS NO: 79636-94-5
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Aldehydes;C9;Carbonyl Compounds
• Mol File: 79636-94-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 68-71 °C(lit.)
• Boiling Point: 302.7 °C at 760 mmHg
• Flash Point: 136.9 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 0.000974mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Air Sensitive
• BRN: 3244183
• CAS DataBase Reference: 5-BROMO-2-ETHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-ETHOXYBENZALDEHYDE(79636-94-5)
• EPA Substance Registry System: 5-BROMO-2-ETHOXYBENZALDEHYDE(79636-94-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 79636-94-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9BrO2/c1-2-12-9-4-3-8(10)5-7(9)6-11/h3-6H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 1761-61-1 5-bromosalicyclaldehyde 
• 149489-18-9 5-bromo-2-ethoxybenzyl alcohol 
• 79636-93-4 4-bromo-1-ethoxy-2-methylbenzene 
• 613-69-4 2-ethoxylbenzaldehyde 

Downstream Products

• 279263-03-5 5-bromo-2-ethyoxyl-benzonitrile 
• 1443430-15-6 2-(5-bromo-2-ethoxyphenyl)-3-hydroxy-4H-chromen-4-one 
• 1443430-06-5 (E)-3-(5-bromo-2-ethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 945997-80-8 trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate 
• 1443655-18-2 (2Z)-[(5-bromo-2-ethoxy)benzylidene]-[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one 
• 1261266-26-5 (2E,5E)-2,5-bis(5-bromo-2 ethoxybenzylidene)cyclopentanone 
• 945997-02-4 C₁₃H₁₉BrO₃ 
• 149489-19-0 2-(5-bromo-2-ethoxyphenyl)ethylamine 

Relevant articles and documents

Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability

We have previously reported a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place preference assays in mice, and do not produce dependence. Although these attributes are promising, these analogues exhibit poor metabolic stability in mouse liver microsomes, likely due to the central tetrahydroquinoline scaffold in this series. As such, a structure-activity relationship (SAR) campaign was pursued to improve their metabolic stability. This resulted in a shift from our original bicyclic tetrahydroquinoline core to a monocyclic benzylic-core system. By eliminating one of the rings in this scaffold and exploring the SAR of this new core, two promising analogues were discovered. These analogues (5l and 5m) had potency and efficacy values at MOR better or comparable to morphine, retained their DOR-antagonist properties, and showed a 10-fold improvement in metabolic stability.

SPIRO AZETIDINE ISOXAZOLE DERIVATIVES AND THEIR USE AS SSTR5 ANTAGONISTS

Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.

5-PHENYLBENZYLAMINE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATES FOR THEIR SYNTHESIS

The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s), ???Ra, Rb1 and Rb2 each represent hydrogen atom, a halogen a