79638-37-2

Upstream product

• 175207-89-3 (S)-2-(allyl-tert-butoxycarbonylamino)-3-phenylpropionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 73270-67-4 (S)-2-allylamino-3-phenyl-propionic acid methyl ester 
• 191337-25-4 (S)-methyl 2-(4-nitrophenylsulphonamido)-3-phenylpropanoate 
• 203873-68-1 (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate 
• 556-56-9 allyl iodid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 292849-74-2 Boc-(Nall)Phe-(Nall)Gly-OEt 

Relevant academic research and scientific papers

Synthesis of cyclic dipeptides by ring-closing metathesis

Several cyclic dipeptides (4a-g and 9a-c) have been synthesized by 'amide-to-amide' cyclization of 2a-g and 8a-c, respectively, by means of ring-closing metathesis employing the Grubbs ruthenium catalyst. The influence of additives as well as the length of the amide substituent were studied. Best yields were obtained by cyclization in solution with either lithium fluoroacetate or α,α-dichlorotoluene as an additive.

Pharmacologically active peptides

Compounds of the formula STR1 and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality; R1 is hydrogen or C1 -C3 primary alkyl; R2 is C1 -C4/s