79673-53-3

Usage

Uses

Used in Pharmaceutical Industry:
(1H-PYRROL-2-YL)-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure and properties make it a valuable component in the creation of new medications.
Used in Chemical Synthesis:
(1H-PYRROL-2-YL)-ACETIC ACID is used as a chemical intermediate for the synthesis of other products. Its versatility in chemical reactions allows it to be a crucial part in the production of a range of compounds.

InChI:InChI=1/C6H7NO2/c8-6(9)4-5-2-1-3-7-5/h1-3,7H,4H2,(H,8,9)

Upstream product

• 4778-25-0 (1H-pyrrol-2-yl)acetic acid ethyl ester 
• 50551-29-6 2-pyrroleacetonitrile 
• 109-97-7 pyrrole 
• 64-69-7 Iodoacetic acid 
• 79791-35-8 2,2,2-trichloro-1-pyrrol-2-yl-ethanol 
• 75-04-7 ethylamine 

Downstream Products

• 636-41-9 2-methyl-1H-pyrrole 
• 92454-14-3 3-Phenyl-2-(1H-pyrrol-2-yl)-propionic acid 
• 92454-16-5 2-(2-phenylethyl)pyrrole 
• 313663-81-9 4,6-dihydrocyclopenta[b]pyrrol-5(1H)-one 
• 89059-09-6 1H-pyrrolizine-2(3H)-one 

Relevant academic research and scientific papers

An enantioselective synthesis of α-alkylated pyrroles: Via cooperative isothiourea/palladium catalysis

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in a manner which points towards potential applications in target directed synthesis.

A one-step radical synthesis of pyrrol-2-acetic acids

Pyrrol-2-acetic acids were generated following a procedure involving I-transfer radical addition of iodoacetic acids to pyrrole with spontaneous loss of HI. This procedure also allows for efficient syntheses of 2-alkyl pyrroles through subsequent thermolytic decarboxylation.

A ONE-STEP CONVERSION OF CERTAIN INDOLE AND PYRROLE GLYOXYLIC ACID ESTERS TO THE CORRESPONDING ACETATES

In this study, a catalytic hydrogen transfer type of hydrogenolysis was developed for the one step conversion of ethyl indole-3-, pyrrole-2- and pyrrole-3-glyoxalates to the corresponding acetates.The structural requirements for this hydrogenolysis were also investigated.

Tetrapyrrole therapeutic agents

This invention relates to new fluorescent mono, di- or polyamide of an aminomonocarboxylic acid and a tetrapyrrole containing at least three carboxy groups of the structure: STR1 wherein Z is the amino acid residue and x is the tetrapyrrole residue and "n" is an integer from 1 to 4 inclusive.

Process for preparing pyrrole-2-acetic acids

N-H and N-loweralkyl pyrrole-2-acetic acids are prepared by the reduction of 1-H and 1-loweralkyl-α-trichloromethylpyrrole-2-methanol with sodium dithionite (sodium hydrosulfite) in the presence of a base, MOH, wherein M is an alkali metal, an alkaline earth metal or tetraalkyl ammonium.

CONTRIBUTION TO THE STUDY OF INDUCTIVE EFFECT TRANSMISSION IN PYRROLE DERIVATIVES

Transmission of the inductive effect in pyrrole derivatives was investigated on 2-ethylpyrrole (VIa), 2-methylpyrrole (VIb), 2-dimethylaminopyrrole (VIc), 2-hydroxymethylpyrrole (VId), methyl 2-pyrrolylacetate (VIe), 2-pyrrolylacetonitrile (VIf), 2-benzenesulfonylmethylpyrrole (VIg) and trimethyl(2-pyrrolylmethyl)ammonium iodide (VIh), by comparison of their relative basicities and acidities.These were determined by IR spectroscopy from the strength of donor-acceptor interactions of the pyrrole derivatives with suitable standard compounds.The found differences show good linear correlations with the ?I substituent constants.On this basis, the transfer of the inductive effect in the given pyrrole series appears to be proportional.