79678-41-4

Upstream product

• 3761-92-0 n-hexylmagnesium bromide 
• 84533-97-1 1-(3-benzyloxyphenyl)-1-methylheptan-1-ol 
• 75-24-1 trimethylaluminum 

Downstream Products

• 70120-16-0 1-bromo-2-benzyloxy-4-(1,1-dimethylheptyl)benzene 

Relevant academic research and scientific papers

Intermediates for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane

Process for making 1-(3-benzyloxyphenyl)-1,1-dimethylheptane, a valuable intermediate for the preparation of analgesic agents, which comprises benzylation of 3-hydroxyacetophenone to produce 3-benzyloxyacetophenone which is converted to 1-(3-benzyloxyphenyl)-1-methylheptan-1-ol via Grignard reaction with n-hexylmagnesium bromide; chlorination of said heptanol by reaction with hydrogen chloride followed by methylation of the thus-produced 1-(3-benzyloxyphenyl)-1-chloro-1-methylheptane with trimethylaluminum.

Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor

Compounds having the formula STR1 wherein STR2 R1 is hydrogen, benzyl or alkanoyl, X is C2-4 alkylene; and Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.