796872-03-2

Upstream product

• 796872-02-1 5-(4-bromo-benzyl)-3-(3,5-dichloro-phenyl)-2-ethylsulfanyl-5-methyl-3,5-dihydro-imidazol-4-one 
• 6590-93-8 3,5-dichlorophenylisothiocyanate 
• 213209-22-4 5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-2-thioxoimidazolidin-4-one 
• 213202-98-3 ethyl 2-amino-2-(4-bromobenzyl)-propanoate 

Downstream Products

• 321723-75-5 5-(4-bromo-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-7H-imidazo[2,1-c][1,2,4]triazol-6-one 
• 796872-04-3 formic acid N'-[4-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-hydrazide 

Relevant academic research and scientific papers

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives

A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inhibito