796872-02-1Relevant articles and documents
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives
Wu, Jiang-Ping,Emeigh, Jonathan,Gao, Donghong A.,Goldberg, Daniel R.,Kuzmich, Daniel,Miao, Clara,Potocki, Ian,Qian, Kevin C.,Sorcek, Ronald J.,Jeanfavre, Deborah D.,Kishimoto, Kei,Mainolfi, Elizabeth A.,Nabozny Jr., Gerald,Peng, Charline,Reilly, Patricia,Rothlein, Robert,Sellati, Rosemarie H.,Woska Jr., Joseph R.,Chen, Shirlynn,Gunn, Jocelyn A.,O'Brien, Drane,Norris, Stephen H.,Kelly, Terence A.
, p. 5356 - 5366 (2007/10/03)
A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inhibito