796875-16-6

Usage

Chemical class

triazole derivatives

Pharmaceutical use

building block for the synthesis of drugs and pharmacologically active compounds

Potential applications

antimicrobial, antifungal, and antiviral agents

Other applications

agrochemicals and material science

Molecular structure

1H-1,2,4-triazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-, methyl ester

Versatility

valuable chemical compound with a range of potential applications in different fields.

Upstream product

• 106-47-8 4-chloro-aniline 
• 796875-13-3 dimethyl [(2,4-dichlorobenzoyl)amino]malonate 
• 50-84-0 2,4 dichlorobenzoic acid 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 1056968-38-7 1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1H-1,2,4-triazole-3-carbonyl chloride 
• 676457-42-4 1-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid 

Relevant academic research and scientific papers

DIARYLTRIAZOLMETHYLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

The invention concerns compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also concerns a method for preparing same and the therapeutic use thereof.

Bioisosteric replacements of the pyrazole moiety of rimonabant: Synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists

Series of thiazoles, triazoles, and imidazoles were designed as bioisosteres, based on the 1,5-diarylpyrazole motif that is present in the potent CB1 receptor antagonist rimonabant (SR141716A, 1). A number of target compounds was synthesized an

Potent imidazole and triazole CB1 receptor antagonists related to SR141716

Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB1 receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analo