79691-72-8Relevant academic research and scientific papers
PYRIMIDINES. 73. SYNTHESIS OF ACETYLPYRIMIDINES
Naumenko, I. I.,Mikhaleva, M. A.,Mamaev, V. P.
, p. 710 - 714 (1981)
It is shown that the use of benzene as the solvent in the preparation of 2- and 4-acetylpyrimidines from cyanopyrimidines via the Grignard reaction makes this reaction a practical method for the preparation of pyrimidinyl ketones.Preparatively convenient methods for the preparation of 4-acetylpyrimidine from 4-ethylpyrimidine through the α-oximino derivative and 5-acetylpyrimidine from 4,6-dichloro derivatives of pyrimidine are proposed.
