Chemistry of Heterocyclic Compounds p. 710 - 714 (1981)
Update date:2022-08-05
Topics:
Naumenko, I. I.
Mikhaleva, M. A.
Mamaev, V. P.
It is shown that the use of benzene as the solvent in the preparation of 2- and 4-acetylpyrimidines from cyanopyrimidines via the Grignard reaction makes this reaction a practical method for the preparation of pyrimidinyl ketones.Preparatively convenient methods for the preparation of 4-acetylpyrimidine from 4-ethylpyrimidine through the α-oximino derivative and 5-acetylpyrimidine from 4,6-dichloro derivatives of pyrimidine are proposed.
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