1422196-72-2Relevant academic research and scientific papers
Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: Insight into substrate recognition
Imamura, Yuki,Umezawa, Naoki,Osawa, Satoko,Shimada, Naoaki,Higo, Takuya,Yokoshima, Satoshi,Fukuyama, Tohru,Iwatsubo, Takeshi,Kato, Nobuki,Tomita, Taisuke,Higuchi, Tsunehiko
, p. 1443 - 1454 (2013)
Substrate-selective inhibition or modulation of the activity of γ-secretase, which is responsible for the generation of amyloid-β peptides, might be an effective strategy for prevention and treatment of Alzheimer's disease. We have shown that helical β-pe
